Product Name :
ROS1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
c ros 1 antibody c ros antibody c ros oncogene 1 receptor tyrosine kinase antibody c Ros receptor tyrosine kinase antibody c ros1 antibody MCF 3 antibody MCF3 antibody Oncogene ROS antibody OTTHUMP00000017814 antibody OTTHUMP00000017815 antibody 展开
Function :
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human ROS 2231-2347/2347
Species reactivity:
Human, Rat
Verify application:
WB, ELISA, FC
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.Price of Doxorubicin (hydrochloride) Avoid repeated freeze/thaw cycles.28269-02-5 web The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.PMID:33599175 When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
258 KDa
Positive control :
Expressed in brain. Expression is increased in primary gliomas.