Product Name :
3,4,5-Trimethoxybenzoyl chloride (CAS 4521-61-3)
Synonym :
Application :
CAS:
4521-61-3
Purity:
≥97%
Molecular Weight:
230.64
Formula :
C10H11O4Cl
Physical state:
Solid
solubility :
Soluble in water(Reacts), and toluene.
Shipping Condition :
Desiccate at 4° C
Melting point:
81-84° C (lit.)
SMILES:
COC1=CC(=CC(=C1OC)OC)C(=O)Cl
References:
:Synthesis of a 3,4,5-trimethoxybenzoyl ester analogue of epigallocatechin-3-gallate (EGCG): a potential route to the natural product green tea catechin, EGCG. | Zaveri, NT. 2001. Org Lett. 3: 843-6. PMID: 11263896Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate. | Sánchez-del-Campo, L., et al. 2008. J Med Chem. 51: 2018-26. PMID: 18324763Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3′,4′,5′-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents. | Ty, N., et al. 2008. Bioorg Med Chem. 16: 7494-503. PMID: 18583138Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(−)-epicatechin. | Sánchez-del-Campo, L. and Rodríguez-López, JN. 2008. Int J Cancer. 123: 2446-55. PMID: 18729182Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006). | Macdonough, MT., et al. 2013. Bioorg Med Chem. 21: 6831-43. PMID: 23993969Synthesis, antimitotic and antivascular activity of 1-(3′,4′,5′-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles. | Romagnoli, R., et al. 2014. J Med Chem. 57: 6795-808. PMID: 250258533-Aryl/Heteroaryl-5-amino-1-(3′,4′,5′-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization. | Romagnoli, R., et al. 2018. Bioorg Chem. 80: 361-374. PMID: 29986184The Protective Effects of Hydrogen Sulfide New Donor Methyl S-(4-Fluorobenzyl)-N-(3,4,5-Trimethoxybenzoyl)-l-Cysteinate on the Ischemic Stroke. | Fan, J., et al. 2022. Molecules. 27: PMID: 35268655The stereochemistry of 5-substituted decahydroisoquinolines and their antiarrhythmic activity. | Mathison, IW., et al. 1968. J Med Chem. 11: 997-1000. PMID: 5697113Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3′,4′,5′-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines. | Lamouri, A., et al. 1993. J Med Chem. 36: 990-1000. PMID: 8478911Design and modeling of new platelet-activating factor antagonists. 2. Synthesis and biological activity of 1,4-bis-(3′,4′,5′-trimethoxybenzoyl)-2-alkyl and 2-alkyloxymethylpiperazines.93608-11-8 web | Tavet, F.7051-34-5 web , et al.PMID:33569720 1997. J Lipid Mediat Cell Signal. 15: 145-59. PMID: 9034961The reaction of diphenyltin (IV) or triphenyltin (IV) chloride with 3,4,5-trimethoxybenzoyl salicylahydrazone. The crystal structure of Ph2[(MeO)3C6H2C(O)N2CHC6H4O]Sn | Zhengkun Yu,Shenggang Yan,Peiju Zheng,Jian Chen. 1995. Heteroatom Chemistry. 6: 513-517.Synthesis and Pharmacological Properties of 1-Aryl-4-(3′4′,5′-trimethoxybenzoyl)piperazines | S. G. Soboleva, A. F. Galatin, T. L. Karaseva, A. V. Golturenko & S. A. Andronati. 2005. Pharmaceutical Chemistry Journal. 39: 236–238.Synthesis and Crystal Structure of 1-(3-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)thiourea | by Aamer Saeed 1,*, Uzma Shaheen 1 and Michael Bolte 2, et al. 2011. Crystals. 1: 34-39.